From Evidence to Impact: Common Conditions

Purpose:
This activity supports clinicians in translating high-impact research published in the New England Journal of Medicine (NEJM) and content in accompanying AMBOSS articles into evidence-based clinical practice. Through structured appraisal and discussion of recent landmark studies, and review of accompanying AMBOSS articles, participants will develop skills in critically evaluating new evidence and determining its relevance to specific patient populations, and will be able to integrate learnings into diagnostic and therapeutic decision-making in everyday clinical care.

Target audience:
Physicians and advanced practice providers in internal medicine who seek to strengthen their evidence-based clinical practice and stay current with rapidly evolving medical research.

Funding source:
None

Content:
The course content was developed jointly by AMBOSS and NEJM Group physician authors and editors. All educational materials are based on best-practice guidelines and high-impact published studies that adhere to accepted standards of scientific evidence. Content is free of commercial bias, and complies with the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education.

Activity type:
Enduring material

Method of participation:
To earn AMA PRA Category 1 Credits™ for this activity, all of the following requirements must be met:

• Complete all 6 modules (i.e., for each module: watch the video, read the linked AMBOSS articles, and complete the practice questions)

• Complete the post-course quiz and achieve a minimum score of 70%.

• Submit the activity evaluation.

1. Describe the underlying disease mechanisms, pathophysiology, and key clinical concepts relevant to each condition addressed.

2. Critically appraise the research question, study design, methodology, and endpoints of the selected NEJM articles to determine the validity and clinical relevance of the evidence.

3. Assess outcomes of the NEJM research presented (including benefits, risks, and limitations) and content in the accompanying AMBOSS articles to guide evidence-based diagnostic and therapeutic decision-making for appropriate patient populations.

4. Summarize clinically relevant findings from the discussed recent NEJM research and accompanying AMBOSS articles to inform patient management strategies and communicate evidence-based clinical reasoning when discussing respective care decisions with colleagues and patients.

Disclosure policy statement

AMBOSS adheres to the policies and guidelines, including the Standards for Integrity and Independence in Accredited Continuing Education (CE), set forth to providers by the Accreditation Council for Continuing Medical Education (ACCME) and all other professional organizations, as applicable, stating that those activities in which continuing education credits are awarded must be balanced, independent, objective, and scientifically rigorous. All persons in a position to control the content of an accredited continuing education program provided by AMBOSS are required to disclose all financial relationships with any ineligible company within the past 24 months to AMBOSS. All financial relationships reported are identified as relevant and mitigated by AMBOSS in accordance with the ACCME Standards for Integrity and Independence in Accredited CE before learners participate in the activity. The content of this activity was vetted by AMBOSS to ensure objectivity and that the activity is free of commercial bias. All relevant financial relationships have been mitigated by AMBOSS. 

Disclosure of relevant financial relationships

The following planners and managers for this activity have the following relevant financial relationships with ineligible companies:

• Blaise Joseph: Stock Shareholder: Xeris Biopharma

All other planners and managers for this activity have no relevant financial relationships with ineligible companies.

The following faculty, authors, and content developers for this activity have the following relevant financial relationships with ineligible companies:

• Elaine W. Yu, MD, MMSc: Contracted Research: Amgen; Stock Shareholder: OPKOpko; Consulting Fees: AbbVie
• Michelle Lai, MD, MPH: Advisory Board: Altimmune, Madrigal; Contracted Research: Madrigal, Inventiva
• Kevin L. Ard, MD, MPH: Contracted Research: Binx, Gilead
• Isaac Kohane, MD, PhD: Advisory Board: Canary Medical
• Caroline M. Mitchell, MD, MPH: Consulting Fees: DIVA, Freya Biosciences; Advisory Board: Concerto Bio, Ancilia Biosciences
• Olga Kantor, MD, MS: Advisory Board: Merck
• Joji Suzuki, MD, FACLP: Contracted Research: Braeburn
• Ole-Petter Hamvnik, MD: Advisory: Merck Manual
• Jan Schlebes: Stock Shareholder: Novo Nordisk; Stock Shareholder: Fresenius SE & Co KGaA

All other faculty, authors, and content developers for this activity have no relevant financial relationships with ineligible companies.

The following content reviewers for this activity have no relevant financial relationships with ineligible companies:

• Lauren Mohar: nothing to disclose

AMBOSS is accredited by the Accreditation Council for Continuing Medical Education (ACCME®) to provide continuing medical education for physicians.  

Physician Credit Designation Statement

AMBOSS designates this enduring material activity for a maximum of 11.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

American Board of Internal Medicine (ABIM) Maintenance of Certification (MOC) Program

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 11.5 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

Original release date: May 3, 2026.

Expiration date: May 2, 2029.

In order to receive a Certificate of Credit (physicians) or a Certificate of Participation (non-physicians) for participation in this activity, learners must complete the evaluation and submit a request for credit.

The evaluation and credit submission request can be accessed at the conclusion of the course on your CME page via https://www.amboss.com/us. Ensure you are in the “Clinical Care” tab, then click on your profile at the top right and on “View your CME page.” Certificates will be automatically generated upon submission of the evaluation. 

The deadline to claim credit is 30 days after the activity expiration date.

For further information about redeeming CME credit and MOC points, please see CME/MOC FAQ.